About Bharath
Bharath Srinivasan studied the structure-function relationship in members of the Haloacid Dehalogenase superfamily of enzymes as part of his PhD studies. He pursued an NIH-sponsored postdoctoral fellowship at the Centre for the Study of Systems Biology, Georgia Institute of Technology, working at the interface between molecular pharmacology, biochemistry/biophysics, computational sciences and medicinal chemistry.
Subsequently, he moved to Portugal with the prestigious Marie Skłodowska-Curie Actions individual fellowship to study the substrate specificity of deaminases acting on double-stranded RNA at the Instituto Gulbenkian de Ciencia, Portugal. Having successfully completed his studies, he relocated to the United Kingdom and transitioned into industry and was a Principal Scientist at the Mechanistic and Structural Biology Division, Discovery Sciences at AstraZeneca, contributing actively for 6 years to several oncology projects deducing the Mechanism of Action of small molecule leads.
Currently, he is a Senior Principal Scientist at the Cancer Research UK contributing to the mechanistic characterization of small molecule-target interaction across the entire portfolio of the organization.
He has published >51 peer-reviewed publications, 1 patent and several science outreach articles. He is an editor with the British Journal of Pharmacology and FEBS Journal. He is also an Honorary Associate Professor of Pharmacy and Life Sciences at the Robert Gordon University, Aberdeen, and a visiting research fellow at the Stony Brook University, NY, USA. He is a fellow of the Royal Society of Biology. He is passionate about molecular pharmacology, biophysical and kinetic characterization of enzymes with particular emphasis on studying the spatio-temporal evolution of kinetic systems, steady state kinetics, pre-steady state kinetics, single turnover kinetics, non-Michaelian kinetics and equilibrium/non-equilibrium modalities of enzyme inhibition especially within the context of drug discovery.