Drug discovery and development
We identify, develop and commercialise promising ideas into successful cancer therapeutics, diagnostics and enabling technologies.
This is the first time a mammalian gene has been shown to have such a direct affect on the lifespan of a mammal.
The discovery was disclosed in a report in Nature (18th November) and has been followed up by the National Press.
Dr Pelicci continues to characterise the function of this important gene that is a splice variant of the SHC locus and has been termed p66shc. The function of the gene appears to be linked with the production of Reactive Oxygen Species and their cumulative damaging effects on the cell. The group has further identified the mechanism for activation of the gene.
